This tumour originates in the fat cells (adipocytes) of the body. It is among the most common subtypes of sarcoma, accounting for approximately 20% of all soft tissue sarcomas. Liposarcomas can occur in various locations throughout the body, but they predominantly develop in the limbs, particularly the thighs and retroperitoneal space (the area behind the abdominal cavity).

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There are different subtypes of liposarcoma, each with distinct characteristics:

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1. Well-differentiated liposarcoma:

This subtype tends to have a more favourable prognosis and may resemble normal fat cells. It tends to grow slowly and forms large, bulky masses.

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2. Dedifferentiated liposarcoma:

In this subtype, there is a mix of more aggressive tumour cells that lack the typical features of well-differentiated liposarcoma. Dedifferentiated liposarcoma can be more challenging to treat and has a higher likelihood of metastasis.

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3. Myxoid or round cell liposarcoma:

This subtype is composed of tumour cells that have a round appearance and produce a gelatinous substance. Myxoid liposarcoma is known for its high rate of recurrence and the potential to metastasize to other parts of the body.